|Peter G. Van Winkle||Wood||Republican||1863||1869|
|Waitman T. Willey||Monongalia||Republican||1863||1871|
|Arthur I. Boreman||Wood||Republican||1869||1875|
|Henry G. Davis||Mineral||Democrat||1871||1883|
|Allen T. Caperton||Monroe||Democrat||1875||1876|
|Johnson N. Camden||Wood||Democrat||1881||1887|
|John E. Kenna||Kanawha||Democrat||1883||1893|
|Charles J. Faulkner||Berkeley||Democrat||1887||1899|
|Johnson N. Camden||Wood||Democrat||1893||1895|
|Stephen B. Elkins||Randolph||Republican||1895||1911|
|Nathan B. Scott||Ohio||Republican||1899||1911|
|Clarence W. Watson||Marion||Democrat||1911||1913|
|William E. Chilton||Kanawha||Democrat||1911||1917|
|Matthew M. Neely||Marion||Democrat||1923||1929|
|Guy D. Goff||Harrison||Republican||1925||1931|
|Henry D. Hatfield||Cabell||Republican||1929||1935|
|1Matthew M. Neely||Marion||Democrat||1931||1941|
|Rush D. Holt||Lewis||Democrat||1935||1941|
|Harley M. Kilgore||Raleigh||Democrat||1941||1956|
|3Hugh Ike Shott, Sr.||Mercer||Republican||1942||1943|
|Matthew M. Neely||Marion||Democrat||1949||1958|
|4William R. Laird, III||Fayette||Democrat||1956||1956|
|5Jack D. Hoblitzell, Jr.||Jackson||Republican||1958||1959|
|7Robert C. Byrd||Raleigh||Democrat||1959||2010|
|John D. Rockefeller IV||Kanawha||Democrat||1985|
|9Joe Manchin III||Marion||Democrat||2010|
1Resigned to become Governor on January 12,
2Appointed by Governor M. M. Neely January 13, 1941, to fill unexpired term of M. M. Neely as U. S. Senator. Served until November 3, 1942.
3Elected for short term from November 3, 1942, to January 3, 1943.
4Appointed March 13, 1956, by Governor W. C. Marland to fill vacancy caused by death of Senator Harley M. Kilgore on February 29, 1956. Served until November 6, 1956.
5Appointed January 25, 1958, by Governor Cecil H. Underwood to fill vacancy caused by death of M. M. Neely on January 18, 1958.
6Elected November 4, 1958, to fill unexpired term ending January, 1961.
7Died on June 28, 2010, while in office.
8Appointed by Governor Joe Manchin, July 16, 2010, to fill unexpired term of Robert C. Byrd until a special election could be held. Served until November 15, 2010.
9Elected November 2, 2010, to fill unexpired term caused by the death of Senator Robert C. Byrd.